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Fall 2023 Skincare Trends: Plant vs Human Stem Cell Skincare

In the ever-evolving world of skincare, breakthroughs and innovations continually emerge, each promising miraculous results. Among these, stem cell-based skincare has gained significant attention. While plant and fruit stem cells have been touted for their skincare benefits, FACTORFIVE Skincare stands apart by harnessing the power of Adult Human Stem Cells (ADSCs) in their products. In this blog, we'll explore the science behind skincare stem cells and discuss why ADSCs are superior to plant and fruit stem cells in the pursuit of youthful, radiant skin, and also the star ingredient in FACTORFIVE Skincare products.

Plant and Fruit Stem Cells: A Closer Look

Plant and fruit stem cells have gained popularity in the skincare industry for their purported regenerative properties. Extracted from botanical sources like apples, grapes, and edelweiss, these stem cells are believed to contain antioxidants, vitamins, and other beneficial compounds that can protect and rejuvenate the skin.

However, there's a fundamental difference between plant and fruit stem cells and human derived ADSCs. Plant and fruit stem cells are adapted to perform specific functions within their respective organisms, such as maintaining plant structure or aiding in fruit development. When applied to human skin, their efficacy may be limited due to the genetic and cellular distinctions between plants and humans.


plant cell and human stem cell


Stem Cell Skincare is NOT ‘Apples to Apples’

Apple stem cell skincare is a type of beauty and skincare product that incorporates stem cells extracted from a specific variety of apple, typically the Uttwiler Spätlauber apple. These apples are known for their remarkable longevity and resistance to environmental stressors, making them an intriguing source for skincare innovation.

While apple stem cell skincare has garnered attention and popularity, there are some considerations to keep in mind:

  1. Scientific Support: The scientific evidence supporting the efficacy of apple stem cells in skincare is limited. While some studies suggest potential benefits, more research is needed to establish their effectiveness definitively.
  2. Individual Variation: Skincare products, including those with apple stem cells, may yield different results for different individuals. Factors such as skin type, age, and overall skincare regimen can influence outcomes.
  3. Complementary Ingredients: The overall effectiveness of an apple stem cell skincare product may depend on its formulation and the presence of other beneficial ingredients.

Apple stem cell skincare is an intriguing concept that aims to harness the potential of plant stem cells for anti-aging and skin rejuvenation. While it offers certain benefits, it may not be as universally effective as human stem cell skincare, which aligns more closely with our skin's biology. 

The Grape Debate

Grape stem cell skincare is a category of beauty and skincare products that utilize stem cells extracted from grapes, particularly from grape varieties known for their high levels of antioxidants and resveratrol. 

Key Characteristics Grape Stem Cell Skincare:

  1. Antioxidant Rich: Grape stem cells are rich in antioxidants, particularly resveratrol and polyphenols. These antioxidants can help protect the skin from free radical damage caused by environmental stressors, such as UV radiation and pollution.
  2. Anti-Aging Potential: Resveratrol, a compound found in grapes, has been studied for its potential to promote skin firmness, reduce the appearance of fine lines and wrinkles, and contribute to a more youthful appearance.
  3. Anti-Inflammatory: Some grape stem cell products may have anti-inflammatory properties, making them suitable for calming and soothing irritated or sensitive skin.
  4. Moisture Retention: Grape stem cell skincare products often claim to enhance moisture retention in the skin, which is essential for maintaining skin hydration and preventing dryness.

Grape stem cell products are often marketed for their potential anti-aging and skin-rejuvenating properties. While grape stem cell skincare offers certain benefits, including antioxidant-rich ingredients like resveratrol, it may not be as effective as human stem cell skincare for addressing complex skin aging concerns. The compatibility, versatility, and efficacy of human stem cells, particularly ADSCs, make them a superior choice for achieving comprehensive anti-aging and skin rejuvenation.

Skincare made for YOUR SKIN: Human Stem Cell Growth Factors

While plant and fruit stem cells have garnered attention, FACTORFIVE Skincare's utilization of Adult Human Stem Cells (ADSCs) sets a new standard for effectiveness and ethical sourcing. The compatibility of ADSCs with human skin, their versatile regenerative properties, and their ability to stimulate collagen production make them a superior choice for anti-aging skincare.

Here’s some of the benefits:

  • Compatibility with Human Skin: ADSCs, derived from adipose (fat) tissue, share a closer genetic and cellular relationship with human skin. This compatibility enables them to interact more effectively with our skin cells, resulting in enhanced rejuvenation and regeneration.
  • Versatile Regenerative Properties: ADSCs possess the remarkable ability to differentiate into various cell types, including fibroblasts, the cells responsible for collagen production. Collagen is vital for maintaining skin's firmness and elasticity, making ADSCs a powerful tool in the fight against aging.
  • Increased Efficacy: Studies have shown that ADSCs can stimulate the production of growth factors and cytokines that promote collagen and elastin synthesis, helping to reduce wrinkles, fine lines, and age-related skin damage. This robust regenerative potential sets ADSCs apart from their plant and fruit counterparts.
  • Ethical Sourcing: FACTORFIVE Skincare is committed to ethical practices in stem cell sourcing. The ADSCs used in their products are derived from excess fat tissue obtained through non-invasive procedures like liposuction, ensuring that no harm comes to donors. This ethical approach distinguishes FACTORFIVE's ADSCs from some other stem cell sources that may raise ethical concerns.

Stem Cells vs Fibroblasts

One of the most common sources of growth factors is a cell from the skin called a fibroblast. Fibroblasts are not stem cells. They are an important member of the skin cell family and have been used as a source for growth factors in skincare since 2001. Public support for fibroblasts in skincare has waxed and waned for years. 

One of the main areas of public unease pertains to the source from which skincare companies get their fibroblast cell stock. Various groups have taken ethical stances against the use of foreskin tissue from infants and the areas of concern have resulted in several class action lawsuits.

Fibroblasts enjoyed a rebound in popularity in 2013 when Oprah Winfrey endorsed a fibroblast-derived skincare product. And while the popularity of fibroblast products has ebbed since that time, FACTORFIVE scientists do believe that fibroblasts are a good source of some types of protein signals. They just aren’t the best source. 

Adult human stem cells (ASCs) are without a doubt the best source of skin remodeling protein signals. ASCs express about 5 times the portfolio of proteins as compared to a fibroblast. As an analogy, if all the protein signals were letters in the alphabet, a fibroblast could give you A through G. An ASC could give you A-Z.

This is an important difference in skin health because many of the most important signals for things like the creation of elastin, antioxidants, immune responsiveness, and tissue remodeling are not found in fibroblast signals. For that reason, FACTORFIVE scientists have looked to ASCs as their tissue source for safe, ethical, and human derived proteins. 

Stem Cells vs Fibroblasts


ADSCs = A Win For Your Skin

When seeking skincare solutions that yield tangible and enduring results, opt for a product that unlocks the full potential of stem cell skincare, such as FACTORFIVE. Say ‘good-bye’  to the confines of plant and fruit stem cells, and embrace the skincare frontier of tomorrow with ADSCs. Your skin deserves nothing short of the very best.


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